Enhancing children’s
lives with biomarkers
for risk stratification
and Triage

About

ISGlobal-led consortium launches EChiLiBRiST, a Project to Reduce Child Mortality in Africa. EChiLiBRiST is a 5-year project, funded by Horizon Europe Research and Innovation Program, which aims to develop and validate a rapid test for early recognition and improved management of febrile children at risk of severe diseases

Clinical Trial 1: Can our test improve current triaging strategies?

in Mozambique and Gabon

Clinical Trial 1: Can our test improve current triaging strategies?

in Mozambique and Gabon

70%

Up to 70% of
severe infections
are missed at triage

90%

Up to 90%
of fevers referred to
tertiary hospitals are mild infections

50% of children at risk die at the community level without access to life-saving interventions

Clinical Trial 2: Can we design a useful treatment based on sTREM-1 levels?

in Mozambique and Ethiopia

Clinical Trial 2: Can we design a useful treatment based on sTREM-1 levels?

in Mozambique and Ethiopia

BEYOND CLINICAL RESEARCH

Beyond a rigorous clinical assessment of the developed product and product-based strategies, EChiLiBRiST will also assess cost-effectiveness, feasibility, acceptability and scalability of the interventions. The data generated will be useful to model and predict impact and cost-savings of the interventions in different scenarios.

Additionally, EChiLiBRiST is fully committed to research capacity building in the African participating countries (Mozambique, Ethiopia and Gabon), which includes the training of 3 African graduates with different disciplinary backgrounds to obtain the PhD.

EChiLiBRiST holds the potential to revolutionize the management of infections in low-income countries and prevent child mortality while saving resources.